Atsuko Masumi Author
Subjects of specialization
Affiliation
Molecular pharmacology
Department of Molecular pharmacology, Faculty of Pharmaceutical Sciences, Aormori University, Japan
Atsuko Masumi is from Department of Molecular pharmacology and Faculty of Pharmaceutical Sciences at Aormori University, 2-3- 1, Kobata, Aomori-shi, Aomori 030-0943, Japan. Atsuko Masumi research interest are Transplantation, Chimerism, Lineage cells.
Research Article Open Access
Author(s): Atsuko Masumi
Objective: Interferon regulatory factor-2 (IRF-2) is highly expressed in hematopoietic stem cells (HSCs) in mouse bone marrow cells. The population of bone marrow Lin-c-Kit+Sca-1+(KSL) cells is increased in IRF-2-/- mice; however, there are less hematopoietic stem cells due to a reduction of the CD150+ population and type I interferon (IFN) signaling. We studied how HSCs lacking IRF-2 differentiate in bone marrow and peripheral blood.
Methods: To study the function of IRF-2 in HSCs, bone marrow cells from IRF-2-/- mice were transplanted into wild-type mice.
Results: Lineage cell population analysis showed that the B220 and CD19 populations from IRF-2-/- mouse bone marrow were enhanced in recipient mice. Conclusion: Bone marrow cells from IRF-2-/-... view moreĀ»