Bahram Alamdary Badlou Author

Short Communication Open Access

Targeting specific gene splicing with Calcium channel inhibitors against the inflammatory effect of bacterial lipopolysaccharide in vivo

Author(s):

Bahram Alamdary Badlou

Trauma patients, who are exposed to bacterial infections i.e. traumatic accidents are at risk to be exposed to so-called “LUCOHAS” (mortal LPSUPR- Calcium Overload Hyper- Activation System). The essential components of LUCOHAS signaling pathway are consist of 4 main key players. The aim of this study is to evaluate induction of inflammatory processes and assess the administration effects at molecular and tissue cytokine changes, in an innovative prepared model system, in vivo. Methods: The LPS was extracted from patients’ burned wounds after Pseudomonas aeruginosa isolation (hLPS), with informed consent. The male c57/BL6 mice divided into 6 groups: 1. Two controls, one received nothing another sterile pyrogen-free normal saline, 3. hLPS (3 mg/kg/ intraperitoneal), 4... view more»

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