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Hindi Endocrinology & Diabetes ResearchISSN: 2470-7570
Baikenova M Author
Subjects of specialization
Affiliation
Diabetes mellitus, Liver, Insulin+ cells
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Biography
The global diabetes epidemic over the past few decades has been one of the leading causes of death worldwide. The search for alternative sources of insulin producing cells in the body may be one of the possible promising approaches to the treatment of diabetes and its complications. The aim of this work was to study changes in the number and localization of insulin+ and Pdx1+ liver cells on the 30th and 60th days at rats with experimental diabetes type 1 and type 2.
Publications
Research Article Open Access
Liver Insulin-Positive Cells in Experimental Diabetes
Author(s): Baikenova M, Sokolova K and Danilova I
The global diabetes epidemic over the past few decades has been one of the leading causes of death worldwide. The search for alternative sources of insulin producing cells in the body may be one of the possible promising approaches to the treatment of diabetes and its complications. The aim of this work was to study changes in the number and localization of insulin+ and Pdx1+ liver cells on the 30th and 60th days at rats with experimental diabetes type 1 and type 2. Experiment was carried out in accordance with the recommendations of European Parliament and of the Council (Directive 2010/63/EU). 35 male Wistar rats weighting 332.6 ± 12.15 g were used. Type 1 diabetes (T1D) was modeled by IP injections of alloxan (170 mg/kg), Type 2 Diabetes (T2D) IP injections of nicotinamide (11... view more»
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