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Hindi Cell Biology: Research & TherapyISSN: 2324-9293
Basso E Author
Subjects of specialization
Affiliation
Neurodegeneration,Tyrosine phosphorylation,Alzheimer?s disease,Diagnostics,Osteoporosis
Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular
Biography
Elisa Basso is closed to defend her PhD in Biomedical Sciences, specializing in Neuroscience at the Faculty of Medicine, Universidade de Lisboa, Portugal. She focused on the study of neurodegenerative disorders. She previously obtained a Master degree in Neurobiology at the University of Pavia and a Bachelor degree in Molecular Biology at the University of Padova.
Publications
Review Article Subscription
NGF and APP Interplay: Focus on YENPTY Motif of Amyloid Precursor Protein and Y682 Residue
Author(s): Basso E and Matrone C
NGF and APP Interplay: Focus on YENPTY Motif of Amyloid Precursor Protein and Y682 Residue
Cholinergic deficits originated from NGF metabolism disruption, represent one of the early changes in Alzheimer’s disease, where abnormal deposition of β-amyloid peptide (Aβ) and phosphorylated Tau define the neuropathological hallmarks of the disorder. A failure in NGF maturation can promote pro-apoptotic pathway activation, through p75 receptor; while lack of NGF signalling can generate an atypical TrkA receptor phosphorylation resulting in neuronal cell death and Aβ toxicity. These evidences suggest a complex interaction between TrkA, p75, and Aβ, whose ... view more»
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