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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Bautista-Lopez NL Author
Subjects of specialization
Affiliation
Colorectal cancer, Cancer chemotherapy, Prostate biomarker, Endometrial cancer
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
Biography
Bautista-Lopez NL was working in the Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada. He has more than 40 publications. His current research area related to osteoarthropathy
Publications
Research Article Open Access
Induction of Increased Levels of Matrix Metalloproteinase-2 (MMP-2) and -9 in Human Breast Cancer Cell Lines by Activation of GM-CSF Receptor Bc via C-Fos-ERK 1/2 Signaling
Author(s): Bautista-Lopez NL, Galipeau J, Cuerquis J, Lalu MM and Eliopoulos N
Background and Objectives: Matrix metalloproteinase (MMP) -2 and -9 play important roles in the invasion and metastasis of breast cancer, but the mechanism of their regulation is not clearly understood. GM-CSF has been shown to be associated with cancer invasion and metastasis. The goal of our study was to examine the stimulation of GM-CSF/ interleukin 3 (IL-3)/IL-5 receptor common β-chain (βc) and its effects on MMP-2 and -9 regulation in human breast cancer cells.
Methods: The constitutive expression of the GM-CSF/IL-3/IL-5 receptor common βc and GM-CSF production were analyzed in BT 549, MCF-7, and MDA-MB 231 human breast cancer cell lines. We studied the effects of reco... view more»
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