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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Bhaskar V.S. Kallakury Author
Subjects of specialization
Affiliation
Voltage-gated sodium channel, Prostate cancer, Prostate biomarker, Gleason score
Department of Pathology, Georgetown University Medical Center, Washington DC, USA
Biography
Bhaskar V.S. Kallakury as working in the Department of Pathology, Georgetown University Medical Center, Washington DC, USA. His current research focuses in drug discovery at Georgetown University Medical Center.
Publications
Research Article Open Access
Expression of Voltage-Gated Sodium Channel Nav1.8 in Human Prostate Cancer is Associated with High Histological Grade
Author(s): Simeng Suy, Todd P. Hansen, Heather D. Auto, Bhaskar V.S. Kallakury, Vernon Dailey, Malika Danner, Linda MacArthur, Ying Zhang, Matthew J. Miessau, Sean P. Collins and Milton L. Brown
Voltage-gated sodium (Nav) channels are required for impulse conductance in excitable tissues. Navs have been linked to human cancers, including prostate. The expression and distribution of Nav isoforms (Nav1.1-Nav1.9) in human prostate cancer are not well established. Here, we evaluated the expression of these isoforms and investigated the expression of Nav1.8 in human prostate cancer tissues. Nav1.8 was highly expressed in all examined cells. Expression of Nav1.1, Nav1.2, and Nav1.9 were high in DU-145, PC-3 and PC-3M cells compared to LNCaP (hormonedependent), C4-2, C4-2B, and CWR22Rv-1 cells. Nav1.5 and Nav1.6 were expressed in all c... view more»
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