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Hindi Research and Reports in Gastroenterology
Cacoub P Author
Subjects of specialization
Affiliation
Eculizumab, Paroxysmal Nocturnal Hemoglobinuria
Department of Internal Medicine, La Piti
Biography
Cacoub P Department of Internal Medicine, La Pitié-Salpêtrière Hospital, Paris, France from the research works Chronic hepatitis C; Paroxysmal Nocturnal Hemoglobinuria; Eculizumab the world’s most expensive drugs and must be administered indefinitely for a sustained response
Publications
Case Report Open Access
Hepatitis C Infection and Paroxysmal Nocturnal Hemoglobinuria with Complicated Course: Coincidental Association or True Link?
Author(s): Chakkor A, Arar A,Sanciu R,Legac E,Cacoub P and Ahmed SNS
Hepatitis C virus (HCV) infection is a major health problem worldwide. It is a well-documented systemic disease whose extra hepatic consequences increase the weight of its pathological burden. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare but life-threatening bone marrow failure disorder that manifests with hemolytic anemia, thrombosis and peripheral blood cytopenia. Fortunately, the introduction of Eculizumab, a humanized monoclonal antibody, has brought a paradigm shift in PNH management and prognosis. We hereby report an unusual association of HCV and PNH which has witnessed persistent breakthrough hemolysis and progression to complications despite Eculizumab. Our report suggests reconsidering the management of PNH patients with HCV especially since the only approved PNH treatm... view more»
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