Journal of Regenerative MedicineISSN: 2325-9620

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Carla MR Lacerda Author

carla.lacerda@ttu.edu

Subjects of specialization
Tissue Engineering, Mechanotransduction, Signaling, Proteomics

Affiliation
Department of Chemical Engineering, Texas Tech University, USA

Biography

Carla MR Lacerda is from Department of Chemical Engineering at Texas Tech University, USA. Carla MR Lacerda  research interest are Valvular cell progenitors, Hematopoietic stem cells, Mesenchymal stem cells, Magnetic separation, Valvular interstitial cells, Regenerative potential, Tissue engineering.

Publications

Research Article Open Access

Progenitor Subpopulations of Valvular Cells Resembling Hematopoietic and Mesenchymal Stem Cells and their Role in Myofibroblastic Activation

Author(s):

Mir S Ali, Xinmei Wang and Carla MR Lacerda

valvular interstitial cells (qVICs) resembling fibroblasts. In diseased valves, a myofibroblastic phenotype, activated VICs (aVICs), is highly proliferative, synthesize extracellular matrix and repair/remodel the valve. Adult valves also have an understudied small population of progenitor cells (pVIC), which can differentiate into other VIC phenotypes. A better understanding is needed for the role of pVIC in valvular pathophysiology. We hypothesize that pVICs mediate deactivation of VICs, to control or prevent pathological development. Methods: In this study, we isolated two subpopulations of pVICs, Mesenchymal Stem Cells (MSC) and Hematopoietic Stem Cells (HSC), and evaluated their role in myofibroblastic deactivation of VICs. Porcine pVIC subpopulations we... view more»

DOI: 10.4172/2325-9620.1000141

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