Carlos J Pirola Author

Short Communication Open Access

Genetics and epigenetics of cardio-metabolic complex diseases

Author(s):

Carlos J Pirola

The metabolic syndrome (MS) constitutes a combination of underlying risk factors for an adverse outcome, cardiovascular disease. Thus, the clinical behavior of the MS can be regarded as a whole. Nevertheless, from a pathogenic point of view, understanding of the underlying mechanisms of each MS intermediate phenotype, obesity, hypertension, type 2 diabetes and particularly insulin resistance is a difficult task. Systems biology introduces a new concept for revealing the pathogenesis of human disorders and suggests the presence of common physiologic processes and molecular networks influencing the risk of a disease. It will be showed a model of this concept to explain the genetic determinants of MS-associated phenotypes. Based on the hypothesis that common physiologic processes and molec... view more»

Abstract PDF