Chandapure Sindhura Author

Short Communication Open Access

Hereditary haemochromatosis

Author(s):

Chandapure Sindhura

Iron is an essential element for the living body. It is stored in human body in the form of ferritin and hemosiderin in various locations like liver, spleen, marrow, duodenum, skeletal muscle and other anatomic areas. Human body lack iron excretion function, the transformation of ferritin into hemosiderin reduces iron toxicity. If there is an increase in level of non transferrin-bound iron, both in whole body iron overload and in localized iron deposition it leads to hazardous free radicals which further leads to various disorders. Hereditary hemochromatosis is generally caused by certain variants in the HFE gene. If two of these variants are inherited, one from each parent, then it leads to hereditary hemochromatosis and risk of developing high iron levels. The faulty haemochromatosis ... view more»

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