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Hindi Journal of Regenerative MedicineISSN: 2325-9620
Chandrasekhar R. Kothapalli Author
Subjects of specialization
Affiliation
Vascular and Neural Tissue Engineering, Applied Microfluidics, Nanotechnology in Biomedicine, Biomaterials, Stem Cell Applications in Regenerative Medicine
Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH 44141, USA
Biography
Dr. Kothapalli earned Bachelor's in Chemical Engineering from Andhra University, India, and Master's degrees in Chemical Engineering and Materials Sciences from Mississippi State University and University of Connecticut, respectively. He received his PhD in Bioengineering from Clemson University in May 2008. His Postdoctoral Fellowship in the Biological Engineering Department at the Massachusetts Institute of Technology was focused on developing microfluidic assays to evaluate neurite responses to growth factor gradients in vitro, investigation of axonal targeting of projection neurons.
Publications
Review Article Subscription
Tissue Engineering Approaches for Motor Neuron Pathway Regeneration
Author(s): Kurt Farrell and Chandrasekhar R. Kothapalli
Tissue Engineering Approaches for Motor Neuron Pathway Regeneration
During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.
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