+44 7460731551Review Article, J Regen Med Vol: 1 Issue: 2
Tissue Engineering Approaches for Motor Neuron Pathway Regeneration
| Kurt Farrell and Chandrasekhar R. Kothapalli* | |
| Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH 44141, USA | |
| Corresponding author : Chandrasekhar R. Kothapalli, PhD Department of Chemical and Biomedical Engineering, Cleveland State University, 2121 Euclid Ave, SH 460, Cleveland, OH 44141, USA Tel: 216-687-2562; Fax: 216-687-9220 E-mail: [email protected] |
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| Received: September 18, 2012 Accepted: October 16, 2012 Published: October 20, 2012 | |
| Citation: Farrell1 K, Kothapalli CR (2012) Tissue Engineering Approaches for Motor Neuron Pathway Regeneration. J Regen Med 1:2. doi:10.4172/2325-9620.1000102 |
Abstract
Tissue Engineering Approaches for Motor Neuron Pathway Regeneration
During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.
