Journal of Regenerative Medicine ISSN: 2325-9620

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Review Article, J Regen Med Vol: 1 Issue: 2

Tissue Engineering Approaches for Motor Neuron Pathway Regeneration

Kurt Farrell and Chandrasekhar R. Kothapalli*
Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH 44141, USA
Corresponding author : Chandrasekhar R. Kothapalli, PhD
Department of Chemical and Biomedical Engineering, Cleveland State University, 2121 Euclid Ave, SH 460, Cleveland, OH 44141, USA
Tel: 216-687-2562; Fax: 216-687-9220
E-mail: [email protected]
Received: September 18, 2012 Accepted: October 16, 2012 Published: October 20, 2012
Citation: Farrell1 K, Kothapalli CR (2012) Tissue Engineering Approaches for Motor Neuron Pathway Regeneration. J Regen Med 1:2. doi:10.4172/2325-9620.1000102

Abstract

Tissue Engineering Approaches for Motor Neuron Pathway Regeneration

During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.

Keywords: Motor neurons; Growth factors; Extracellular matrix; Animal models; Tissue engineering; Regenerative medicine; Drug delivery; Central nervous system

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