Chang Ran Zhang Author
Subjects of specialization
Affiliation
Systemic lupus erythematosus; Bacille Calmette Guerin;Vaccination; Complement; Therapy; Immunology
Department of Internal Medicine, Huang Pu Hospital of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510700, China
Dr. Chang Ran Zhang was an assistant professor of Department of Internal Medicine, Huang Pu Hospital of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510700, China and later he started his career in Therapeutic Action Research of Bacille Calmette Guerin (BCG) on a Systemic Lupus Erythematosus Mouse Model
Research Article Open Access
Author(s): Chen biao YU, Ren Jiang, Yuan yuan Niu, Wei Shiu, Qian Gao and Chang Ran Zhang
Background: We have been determined that for patients with systemic lupus erythematosus (SLE), after becoming infected with tuberculosis, the damages in their hematologic and complement systems were alleviated to a certain extent, this was an interesting phenomenon. So we hypothesized that tuberculosis infection could be useful for treating the SLE activity.
Methods: In order to verify the above research conclusions, the animal experiments were conducted in combination with an SLE model mouse with BCG vaccinations.
Results: The research results showed that, for the mice receiving BCG vaccinations, the serum protein complement C4 concentration was significantly higher than that of the normal sal... view moreĀ»