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Hindi International Journal of Theranostics
Daniela Tosoni Author
Subjects of specialization
Affiliation
breast carcinogenesis, Oncology, Molecular Medicine
European Institute of Oncology, Italy European Institute of Oncology, Italy European Institute of Oncology, Italy
Biography
Daniela Tosoni has completed her PhD from The European Institute of Oncology and Yale University and postdoctoral studies from The European Institute of Oncology and The FIRC Institute for Molecular Oncology in Milan. She is a Staff Scientistic and the Coordinator of Stem Cell and Preclinical Model Unit of the Program of Molecular Medicine at European Institute of Oncology.
Molecular Medicine, Oncology,breast carcinogenesis
Publications
Review Article Open Access
Loss of Numb in breast carcinogenesis: a paradigm for a mechanism-based selective anti-cancer stem cell therapy
Author(s): Daniela Tosoni
The cell fate determinant Numb could be a tumour suppressor within the exocrine gland whose loss in human breast cancers ends up in p53 inactivation Associate in Nursingd an aggressive malady course. Numb-p53 downregulation results in aberrant exocrine gland ontogeny and emergence of cancer stem cells (CSCs). Numb-deficient CSCs show unlimited self-renewal and proliferative potential, that could be a operate of their ability to execute unbridled self-renewing isobilateral divisions. These phenotypes that may be reverted by Numb-p53 restoration during a Numb-knockout mouse model, disceptation that targeting Numb-p53 disfunction in Numb-deficient human carcinoma might represent a completely unique anti-CSC medical aid. mistreatment patient-derived xenografts, we’ve got recently inco... view more»
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