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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Eliopoulos N Author
Subjects of specialization
Affiliation
Colorectal cancer, Cancer chemotherapy, Prostate biomarker, Endometrial cancer
Department of Surgery, Division of Surgical Research, McGill University, 3999 Cote Ste-Catherine Road, Montreal, Quebec, H3T 1E2 Canada
Biography
Eliopoulos N was working in the Department of Surgery, Division of Surgical Research, McGill University, Lady Davis Institute for Medical Research, Jewish General Hospital, 3999 Cote Ste-Catherine Road, Montreal, Quebec, H3T 1E2 Canada.
Publications
Research Article Open Access
Induction of Increased Levels of Matrix Metalloproteinase-2 (MMP-2) and -9 in Human Breast Cancer Cell Lines by Activation of GM-CSF Receptor Bc via C-Fos-ERK 1/2 Signaling
Author(s): Bautista-Lopez NL, Galipeau J, Cuerquis J, Lalu MM and Eliopoulos N
Background and Objectives: Matrix metalloproteinase (MMP) -2 and -9 play important roles in the invasion and metastasis of breast cancer, but the mechanism of their regulation is not clearly understood. GM-CSF has been shown to be associated with cancer invasion and metastasis. The goal of our study was to examine the stimulation of GM-CSF/ interleukin 3 (IL-3)/IL-5 receptor common β-chain (βc) and its effects on MMP-2 and -9 regulation in human breast cancer cells.
Methods: The constitutive expression of the GM-CSF/IL-3/IL-5 receptor common βc and GM-CSF production were analyzed in BT 549, MCF-7, and MDA-MB 231 human breast cancer cell lines. We studied the effects of reco... view more»
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