Ester Boix Author

Short Communication Open Access

Human Ribonucleases and Derived peptides to Tackle Antimicrobial Resistance

Author(s):

Ester Boix

Emergence of bacterial resistance to most common antibiotics
urges the design of novel antimicrobial drugs. Antimicrobial
proteins andpeptides (AMPPs) are key players of the host innate
immunity and exert a rapid and multifaceted action that reduces
the development of bacterial adaptation mechanisms. Our research
group has been long-time exploring the mechanism of action
of human ribonucleases involved in host defence. Human host
defence RNases is members of the vertebrate specific RNase A
superfamily. They are expressed by a diversity of innate immune
cells and are endowed with antimicrobial properties. Secreted
upon infection, they contribute to protect our body fluids from
invading pathogens. We have identif... view more»

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