Federico Brucoli Author

Short Communication Open Access

DNA-Minor Groove as a Molecular Target for the Design of Highly-Effective Anti-Tubercular Agents

Author(s):

Federico Brucoli

Tuberculosis (TB) is one of the top ten killers worldwide and remains
the leading cause of death among infectious diseases. There is still
a limited number of validated TB targets and it is crucial to identify
novel, or re-purpose existing, molecular targets to generate new
anti-tubercular drugs to fight the tuberculosis pandemic. To this
end, the well-characterised DNA-minor groove might be used to
develop highly-effective anti-tubercular probes with a mechanism
of action, i.e., DNA-binding, different from that of current TB
drugs. DNA-minor groove binding agents can recognise discrete
DNA sequence, modulate the activity of transcription factors and
ultimately cause cell death. Libraries of distamycin analogues
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