Fernando SSNand Gunasekara TDCP Author

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Circulating Micro RNA 21 Levels in Gastric Cancer Patients in Sri Lanka and Role of Helicobacter pylori as a Risk for Development of Gastric Cancer.

Author(s):

Ubhayawardana DLNL, Nisansala GGT, Arachchi PS, Rajakaruna K, Wanigasekera DK, Gunasekera D, Seneviratne MBS, Weerasekera D, Weerasekera MM, Fernando SSN and Gunasekara TDCP

Background: Gastric cancer is the second leading cause of cancer-related mortality and the fourth most common cancer globally. This study was conducted to evaluate the usefulness of miR-21 as a less invasive screening and prognostic marker in Gastric cancer patients from Sri Lanka. Further the H. pylori status was investigated.

Methods: Twenty patients who were diagnosed as having gastric cancer were enrolled along with the age sex matched healthy controls in this study. Specimens and clinicopathologic features of the patients were collected at 2 teaching hospitals. Circulating miR-21 levels in serum were quantified by real time PCR using miR-16 as a normalization control. The serum of each patient with gastric cancer was tested for t... view more»

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