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Hindi Journal of Molecular Biology and Methods
Firdausi Aliyu Author
Affiliation
Faculty of Biosciences and Medical Engineering, Department of Biotechnology and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Johor, Malaysia
Biography
Firdausi Aliyu Faculty of Biosciences and Medical Engineering, Department of Biotechnology and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Johor, Malaysia, His Research Interest is Cell Culture
Publications
Review Article Open Access
Molecular Basis and Engineering of Enzymes Stereospecificity
Author(s): Aliyu Adamu, Firdausi Aliyu, Fahrul Huyop and Roswanira Abdul Wahab
Molecular recognition, particularly enantiomeric specificity of biological molecules is a key consideration in designing drugs, pharmaceutical intermediate and in industrial production of chirally active intermediate. Although the molecular bases of many enzymes stereospecificity are not completely delineated, a number of protein engineering studies were able to enhance and even in some cases invert the stereospecificity of various enzymes. Herein, we review the current understanding on enzymes stereospecificity, and the effects of mutations to the stereospecific pockets due to enzymes engineering to improve stereospecificity.
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