Gaetano Urso Author

Research Article Open Access

Short-Term Comparison of Magnetic Resonance Imaging and Spectroscopy in Persistent Canine Hepatic Encephalopathy Before and After Treatment

Author(s):

Mario Dolera, Luca Malfassi, Cristina Bianchi, Nancy Carrara, Sara Finesso, Silvia Marcarini, Giovanni Mazza, Simone Pavesi, Massimo Sala and Gaetano Urso

Objective: To compare magnetic resonance imaging (MRI) and spectroscopy (MRS) findings in dogs affected by persistent hepatic encephalopathy (HE) before and after treatment and assess any correlation between plasma ammonia levels and metabolite concentrations.
Methods: In dogs with persistent HE, plasma ammonia measurement, brain MRI and single voxel MRS were performed before and 4 months after treatment. The concentrations of N-acetyl aspartate, (NAA) glutamate-glutamine complex (Glx), creatine (Cr), choline (Cho) and myo-inositol (mI) as well as the MRI findings were
compared and the correlation with plasma ammonia concentration was evaluated. Statistical analysis included Shapiro Wilk test, Student t-test and linear-fit regression.
Results:... view more»

DOI: 10.4172/2325-9590.1000240

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