Gaku Fukuhara | Author | SciTechnol | Cell Biology: Research & T

Gaku Fukuhara Author

Subjects of specialization
Cellular Immunology,Cellular Pathology,Cell Regeneration,Cell Regeneration,Medicine

Affiliation
Associate Professor, Department of Internal Medicine

Biography

He has international experience on various programs, and also contributed and participated in different countries for diverse fields of study. Research interests reflect in wide range of publications in various national and international journals.

Publications

Short Communication Open Access

Pharmaceutical Oligosaccharide sensing by a chemical approach

Author(s):

Gaku Fukuhara

Selective sensing of oligosaccharides in aqueous media is a challenge in current chemistry due to their heavy hydration and stereochemical diversity. us, the develop¬ment of selective saccharide sensor that functions in aqueous media is of particular signi cance and bene t not only from the scienti c but also from the application point of view. In this study, we synthesized reporter-modi ed curdlan (DABz-Cur) as a saccharide chemosensor, and investi¬gated its abilities for sensing a variety of oligosaccharides by using circular dichroism spectroscopy to nd a speci cally high sensitivity for one of tetrasaccharides, i.e. acarbose shown in Figure 1a. Acarbose is a drug to treat type-2 diabetes mellitus and obesity by inhibiting α-glu... view more»

Abstract PDF