Gerhard Opelz Author

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Increased Serum Kynurenine Level is Associated with Severity of Kidney Injury in Puumala Hantavirus Infection

Author(s): Mahmoud Sadeghi, Imad Lahdou, Stefan Mehrle, MojdehHeidary Navid, Volker Daniel, Martin Zeier, Paul Schnitzler, Gerhard Opelz and Peter Terness

Background: Nephropathiaepidemica (NE) caused by Puumalahantavirus is a mild type of hemorrhagic fever with renal syndrome (HFRS). An immune-mediated pathogenesis is discussed for NE. Catabolism of tryptophan (Trp) along the kynurenine (Kyn) pathway is dependent on indoleamine 2,3-dioxygenase (IDO), an enzyme whose activity is induced during immune responses. Because viral infections can induce strong immune responses, we wanted to analyse whether there is a correlation between the severity of HFRS and Kyn or Trp serum concentration.
Methods: We retrospectively studied 60 patients hospitalised with acute Puumalahantavirus infection during an epidemic in Germany in the year 2012. The infection was confirmed by positive antihantavirus IgG and IgM ... view more»

DOI: 10.4172/2324-8955.1000130

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