Ghaleb Bin Huraib Author

Special Issue Article Open Access

Interferon –γ Gene Polymorphism as a Biochemical Marker for Atopic dermatitis in Saudis

Author(s):

Ghaleb Bin Huraib 

Atopic dermatitis (AD), also known as atopic eczema, is a chronic inflammatory skin disease characterized by severe itching and recurrent, relapsing eczema-like skin lesions, affecting up to 15% of children in industrialized countries. AD is a complex multifactorial disease, and its exact etiology and pathogenesis have not been fully elucidated. The aim of this study was to investigate the impact of gene polymorphisms of T helper cell subtype Th1 cytokine, interferon-gamma (IFN-γ) on AD susceptibility in a Saudi cohort.  Hundred four unrelated patients with AD and 195 healthy controls were genotyped for IFN-γ (874A/T) polymorphism. Genomic DNA was separated from the fringe blood of AD patients and controls utilizing the QIAampR DNA little unit. IFN-γ quality was e... view more»

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