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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Hackenberg S Author
Subjects of specialization
Affiliation
Colorectal cancer, Cancer chemotherapy, Facial tumour
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Wuerzburg, Germany
Biography
Hackenberg S was working in the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Wuerzburg, Germany. He has more than 40 publications. His current research area related to osteoarthropathy.
Publications
Research Article Open Access
Pre-Irradiated Fibroblasts Influence the Chemosensitivity of Co-Cultivated Squamous Cell Carcinoma Cells
Author(s): Gehrke T, Scherzad A, Hackenberg S, Ickrath P, Schendzielorz P, Hagen R and Kleinsasser N
Objective: Tumor stroma mainly consists of fibroblasts, which have a multitude of interactions with the cancer cells they surround. Since irradiation and chemotherapy are common therapeutic options for squamous cell carcinoma of the head and neck, the effects of irradiation on tumor stroma and their sensitivity to chemotherapeutic agents are of significant therapeutic interest.
Methods: FaDu head and neck squamous cell carcinoma cells (HNSCC) were cultivated with fibroblasts from pre-irradiated and non-irradiated human skin for 24 hours. Then the co-cultures were treated with either Cisplatin, Paclitaxel or 5-Fluorouracil for 48 hours. Analysis of tumor viability and apoptosis were conduc... view more»
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