Huabin Wang Author

Annual Meeting Abstract Open Access

Urinary orosomucoid 1 protein to creatinine ratio as a potential biomarker for early screening of kidney impairment in type-2 diabetes patients

Author(s):

Huabin Wang

Early screening of diabetic kidney disease (DKD) remains a major challenge. Our aim was to evaluate the value of urinary orosomucoid 1 protein (UORM1) in early renal impairment screening in type-2 diabetes patients. Methods: The concentration of UORM1, the UORM1-to-creatinine ratio (UORM1CR), the urinary albumin-to-creatinine ratio (ACR), the alpha-1-microglobulin-to-creatinine ratio (A1MCR), and eGFR were measured in 406 type-2 diabetes patients. Any positive values for ACR, A1MCR, and/or eGFR were considered as indicative of renal impairment. Results: On average, the levels of UORM1 and UORM1CR were about 7-times higher in subjects with renal injury than in those without. Both UORM1 and UORM1CR, when adjusted via logarithm-transformation, were significantly related to ACR, A1MCR, and ... view more»

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