Jacob J Schlesinger | Author | SciTechnol

Jacob J Schlesinger Author

xjin@ips.ac.cn 86-21-5492-3076 | 86-21-5492-3

Subjects of specialization
Dengue; Antibody-dependent enhancement; Burst size

Affiliation
Department of Medicine, University of Rochester, Rochester, New York 14642, USA

Biography

Dr. Jacob Schlesinger was an Assistant Professor of Department of Medicine, University of Rochester, Rochester, New York 14642, USA and he started his career in Increased Virus Uptake Alone is Insufficient to Account for Viral Burst Size Increase during Antibody-Dependent Enhancement of Dengue Viral Infection

Publications

Short Communication Open Access

Increased Virus Uptake Alone is Insufficient to Account for Viral Burst Size Increase during Antibody-Dependent Enhancement of Dengue Viral Infection

Author(s):

Matthew Quinn, Zhihua Kou, Luis Martinez-Sobrido, Jacob J Schlesinger and Xia Jin

Increased Virus Uptake Alone is Insufficient to Account for Viral Burst Size Increase during Antibody-Dependent Enhancement of Dengue Viral Infection

Antibody-dependent enhancement (ADE) is a generally accepted hypothesis to explain increased viremia and disease severity during secondary human DENV infections. In addition to an increased number of infected cells, its mechanism has been postulated as either an increased uptake or an elevated production of viruses per infected cell during ADE infection. The latter postulate, however, has not been rigorously tested. Using Fc gamma receptor (Fcϒ R)-positive and type I IFN-positive (THP-1 and U937) or negative (K562) huma... view more»

DOI: 10.4172/2329-9541.1000111

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