James Miess Author

Research Article Open Access

Cortical and Cancellous Bone Regeneration in Cranioplasty and Spinal Arthrodesis Models Using Autologous Homologous Bone Construct (AHBC)

Author(s):

Pratima Labroo*, Nicholas Baetz, Marytheresa Ifediba, Kendall Stauffer, Michael Sieverts, Jessie Johnson, Eric Chan, Ian Robinson, James Miess, Jennifer Irvin, Lyssa Lambert, Caroline Garrett, Edward W. Swanson, and Nikolai A. Sopko
 

Autologous bone grafts are commonly used to treat large bone defects. Though autologous bone grafts have high rates of success, they are limited by availability of donor tissue and may not be suitable for all treatment pathologies. Allografts are an attractive alternative as they do not utilize tissue from the patient but have a higher risk of infection and graft failure. In this study, an autologous homologous bone construct (AHBC) derived from viable bone, was compared to autologous bone grafts and demineralized bone matrix in rabbit models of critical-sized cranial defects and spinal fusion. AHBC is made from a small bone harvest obtained from an uninjured area of the patient. Without any exogenous supplementation or culturing, the AHBC is expeditiously deployed to the treatment site... view more»

Abstract HTML PDF