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Hindi Journal of Virology & Antiviral ResearchISSN: 2324-8955
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Jay C Brown Author
Subjects of specialization
Affiliation
Herpes Simplex Virus Capsid, Microbiology,, Immunology, Cancer Biology
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Biography
Jay C Brown is a Professor of Microbiology, Immunology, and Cancer Biology at University of Virginia Cancer Center, USA . He obtained his BA in Johns Hopkins University, Baltimore.He was awarded the Ph.D. at Harvard University, Cambridge, USA. Brown was a post-doctoral fellow at MRC Lab of Molecular Biology, Cambridge UK. His major research interests focus on Structure and Assembly of the Herpes Simplex Virus Capsid. The Brown lab studies herpesvirus infections that affect cancer patients with emphasis on HSV-1 and KSHV.
Publications
Research Article Open Access
Control of Host Gene Expression by a Herpesvirus Transcription Factor
Author(s): Jay C Brown
Herpes simplex virus and other alpha-herpesviruses encode a transcription factor, VP16, able to activate expression of genes containing its binding site (TAATGARAT) in the promoter region. VP16 protein is present inside the infectious virion and it enters the host cell with the virus nucleocapsid. Once inside the cell, VP16 is able to cause the prompt expression of virus genes adjacent to its binding sites. I have examined the possibility that host gene expression may have the po... view more»
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