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Hindi Endocrinology & Diabetes ResearchISSN: 2470-7570
Jean Paul Cristol Author
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XO activity increased in chronic kidney failure, caused by adenine administration
INRAE_International XO activity increased in chronic kidney failure, caused by adenine administration
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XO activity increased in chronic kidney failure, caused by adenine administration ContextGlycemic disorders, one of the main risk factors for cardiovascular disease, are associated with activation of oxidative stress. ObjectiveTo assess the respective contributions of sustained chronic hyperglycemia and of acute glucose fluctuations
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Xanthine Oxidase is Variably Involved in Nutritional and Physio-Pathologic Oxidative Stress Situations
Author(s): Christine Feillet-Coudray, Gilles Fouret, B?atrice Bonafos, Manar Aoun, Julie Carillon, Thibault Sutra, Caroline Laurent, Jean Max Rouanet, Dominique Lacan, Jean Paul Cristol and Charles Coudray
Xanthine Oxidase is Variably Involved in Nutritional and Physio-Pathologic Oxidative Stress Situations
High random ROS production leads to generalised oxidative stress that is involved in aging and degenerative diseases, such diabetes or chronic kidney failure. The major cellular ROS sources are mitochondria and NADPH oxidase, and xanthine oxidase (XO). XO is known to be involved in ischemiareperfusion oxidative stress damages, but little is known about its possible involvement in other nutritional and physio-pathologic oxidative stress situations.
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