Jin-Song Gao | Author | SciTechnol | Cell Biology: Research & Th

Jin-Song Gao Author

Suzanne_DeLaMonte_MD@Brown.edu

Subjects of specialization
Pharmacology,Physiology,Cell gene therapy,Diagnostics,Osteoporosis

Affiliation
Molecular Pharmacology and Physiology Graduate Program, Brown University, Providence, RI, USA

Biography

Jin-Song Gao is currently working in Molecular Pharmacology and Physiology Graduate Program, Brown University, Providence, RI, USA. He has international experience on various programs, and also contributed and participated in different countries for diverse fields of study. Research interests reflect in wide range of publications in various national and international journals

Publications

Research Article Open Access

Phosphorylation Modulates Aspartyl-(Asparaginyl)-Î²- Hydroxylase Protein Expression, Catalytic Activity and Migration in Human Immature Neuronal Cerebellar Cells

Author(s):

Ming Tong, Jin-Song Gao, Diana Borgas, Suzanne M. de la Monte

Background: Abundant aspartyl-asparaginyl-β-hydroxylase (ASPH) expression supports robust neuronal migration during development, and reduced ASPH expression and function, as occur in fetal alcohol spectrum disorder, impair cerebellar neuron migration. ASPH mediates its effects on cell migration via hydroxylation-dependent activation of Notch signaling networks. Insulin and Insulin-like growth factor (IGF-1) stimulate ASPH mRNA transcription and enhance ASPH protein expression by inhibiting Glycogen Synthase Kinase--3β (GSK-3β). This study examines the role of direct GSK-3β phosphorylation as a modulator of ASPH protein expression and function in human cerebellar-derived PNET2 cells.
Methods: Predicted phosphorylation sites encod... view more»

DOI: 10.4172/2324-9293.1000133

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