Johanes Nugroho1 Author

Research Article Open Access

The Relationship of HSP-70 with Calcineurin, Sod and Catalase Post-Acute Myocardial Infarction in Wistar Rats Model

Author(s):

Johanes Nugroho1,2*, Christo Darius2, Maria Yolanda Probohoesodo3, Suhartono Taat Putra4 and Cornelia Ghea5

Background: HSP-70s help to reduce infarct area through unclear mechanism. It appears that HSP-70 activates calcineurin and induce antioxidant enzymes such as Superoxide Dismutase (SOD) and catalase. Therefore, we sought to investigate the relationship of HSP-70 with calcineurin, SOD and catalase post-Acute Myocardial Infarction (AMI). Methods: An experimental study involved 24 Wistar rats as models of chronic coronary occlusion. The rats were randomly divided into 4 groups: no-intervention after AMI (N), sedentary intervention after AMI (S), exercise intervention after AMI (E), and sham (C). Intervention consisted of 2 weeks of recovery then 4 weeks of sedentary for group S or exercise for group E. HSP-70, calcineurin, SOD, and catalase expression in heart were evaluated the difference... view more»

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