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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Josua DeckerDagger; Author
Subjects of specialization
Affiliation
Prostatitis, Mitogens, Prostate cancer
Institute of Pathology, University of Ulm, Albert-Einstein-Allee 23, 89070 Ulm, Germany
Biography
Josua DeckerDagger was working at Institute of Pathology, University of Ulm, Albert-Einstein-Allee 23, 89070 Ulm, Germany. He has more than 40 publications. His current research area related to osteoarthropathy.
Publications
Research Article Open Access
Loss of the Tumor Suppressor NKX3.1 in Prostate Cancer Cells is Induced by Prostatitis Related Mitogens
Author(s): Josua Decker‡, Garima Jain‡, Tina Kießling, Philip Sander, Margit Rid, Thomas TF Barth, Peter Möller, Marcus V Cronauer and Ralf B Marienfeld
Objective: Prostate carcinoma (PCa) is the leading causes of cancer-related death in elderly men. Although several risk factors for the development of prostate cancer have been identified, the impact of chronic prostatitis is still a matter of debate. A key event of prostate cancer pathogenesis is the decrease of the homeo box protein NKX3.1 in the luminal epithelial cells of the prostate observed in early pre-cancerous lesions. Furthermore, inactivation of Nkx3.1 in a mouse model led to high incidence of prostatic intraepithelial neoplasia (PIN) formation underscoring the importance of NKX3.1 loss. In this study, we aimed to define t... view more»
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