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Hindi Cell Biology: Research & TherapyISSN: 2324-9293
Jozef Oleksyszyn Author
Subjects of specialization
Affiliation
Cell Developmental Biology,Cell Motility and Differentiation,Cell Tissue Studies
Wroclaw University of Technology, Poland
Biography
Józef Oleksyszyn has received his PhD (1974-1977) and DS (Doctor of Sciences, Habilitation, 1978-1986) from Faculty of Chemistry, Wroc?aw University of Technology, Poland. Currently, he is a Professor of Biochemistry at Wroc?aw University of Technology, Poland. He had two Post-doctoral Scholarship, the first (1982-1984) in the Department of Chemistry, Michigan University under Professor Arthur Ashe and the second one at Georgia Institute of Technology under Professor James C Powers.
Publications
Editorial Open Access
The Problems with the Cells Based Assays
Author(s): Jozef Oleksyszyn
The Problems with the Cells Based Assays
An important part of the classical drug discovery paradigm is the cell based assay. Medicinal chemists, after identification of the molecular target such as enzyme or receptor are quite efficient with the design and synthesis of a potential inhibitor or receptor antagonist. If crystal structure of the target proteins is available, computer modeling accelerated the overall process substantially. Also the combinatorial libraries could supply a large number of interesting new chemical structures. In a relative short time, medicinal chemistry could create a large number of the potent inhibitors or receptor a... view more»
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