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Hindi Endocrinology & Diabetes ResearchISSN: 2470-7570
Julie Carillon Author
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XO activity increased in chronic kidney failure, caused by adenine administration
INRAE_International XO activity increased in chronic kidney failure, caused by adenine administration
Biography
XO activity increased in chronic kidney failure, caused by adenine administration Oxidative stress, involved in many diseases, is defined as an impaired balance between reactive oxygen species (ROS) production and antioxidant defences. Antioxidant enzymes such as superoxide dismutase (SOD) play a key role in diminishing oxidative stress
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Xanthine Oxidase is Variably Involved in Nutritional and Physio-Pathologic Oxidative Stress Situations
Author(s): Christine Feillet-Coudray, Gilles Fouret, B?atrice Bonafos, Manar Aoun, Julie Carillon, Thibault Sutra, Caroline Laurent, Jean Max Rouanet, Dominique Lacan, Jean Paul Cristol and Charles Coudray
Xanthine Oxidase is Variably Involved in Nutritional and Physio-Pathologic Oxidative Stress Situations
High random ROS production leads to generalised oxidative stress that is involved in aging and degenerative diseases, such diabetes or chronic kidney failure. The major cellular ROS sources are mitochondria and NADPH oxidase, and xanthine oxidase (XO). XO is known to be involved in ischemiareperfusion oxidative stress damages, but little is known about its possible involvement in other nutritional and physio-pathologic oxidative stress situations.
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