Katherine Nanos5 Author

Short Communication Open Access

Laboratory Quantification of Bone Marrow Concentrate Components in Unilateral Versus Bilateral Posterior Superior Iliac Spine Aspiration

Author(s):

Kenneth Mautner1,2, Mairin A. Jerome3 , Kirk Easley4 , Katherine Nanos5 , Peter A. Everts6

Mesenchymal Stem Cells (MSCs) from Bone Marrow Concentrate (BMC) have emerged as a promising treatment for degenerative musculoskeletal pathologies, such as Osteoarthritis (OA). Many aspiration techniques have been described in the literature with little consensus on optimal methodology. This study aimed to compare MSC quantity in unilateral versus bilateral Posterior Superior Iliac Spine (PSIS) bone marrow aspirate concentrations. Patients with unilateral knee OA seeking treatment with intraarticular BMC were recruited and randomized to a unilateral PSIS Bone Marrow Aspiration (BMA) or a bilateral PSIS BMA of equal total volumes. BMA and BMC samples underwent laboratory analysis of Colony Forming Unit-Fibroblasts (CFU-fs) as a marker for MSCs, for quantification of Total Nucleated Cell... view more»

Abstract PDF