Keshvad hedayatyanfard Author

Special Issue Article Open Access

Chitosan/PVA/Doxycycline film and nanofiber accelerate diabetic wound healing in a Rat model

Author(s):

Keshvad hedayatyanfard

In this study we evaluated the effects of nanofiber and film polymers with doxycycline for treating wound in a diabetic rat model. 108 male rats were divided into six groups, the control group, the diabetic control, and the groups were diabetic rats receiving different wound dressing. At the 3rd, 7th, and 14th days, macroscopic/histologic imaging and tissue sampling was performed. Tissues were analyzed for IL-1β, TNF-α, IL-10, TIMP-1, and MMP-2 by using ELISA. Dressings of chitosan, PVA and doxycycline increased the rate of wound closure, the volume of collagen, dermal, and epidermis; in addition it increased the number of fibroblasts and basal cell epidermis cells, vascular length, and decreased the number of neutrophil cells. Inflammatory cytokines and MMP-2 were decreased,... view more»

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