Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Lalu MM Author

Subjects of specialization
Elderly, Cancer chemotherapy, Prostate biomarker, Endometrial cancer

Affiliation
Department of Anesthesiology, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Biography

Lalu MM was working in the Department of Anesthesiology, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. He has more than 200 publications. His current research area related to oncology. 


Publications

Research Article Open Access

Induction of Increased Levels of Matrix Metalloproteinase-2 (MMP-2) and -9 in Human Breast Cancer Cell Lines by Activation of GM-CSF Receptor Bc via C-Fos-ERK 1/2 Signaling

Author(s):

Bautista-Lopez NL, Galipeau J, Cuerquis J, Lalu MM and Eliopoulos N

Background and Objectives: Matrix metalloproteinase (MMP) -2 and -9 play important roles in the invasion and metastasis of breast cancer, but the mechanism of their regulation is not clearly understood. GM-CSF has been shown to be associated with cancer invasion and metastasis. The goal of our study was to examine the stimulation of GM-CSF/ interleukin 3 (IL-3)/IL-5 receptor common β-chain (βc) and its effects on MMP-2 and -9 regulation in human breast cancer cells.

Methods: The constitutive expression of the GM-CSF/IL-3/IL-5 receptor common βc and GM-CSF production were analyzed in BT 549, MCF-7, and MDA-MB 231 human breast cancer cell lines. We studied the effects of reco... view moreĀ»

DOI: 10.4172/2324-9110.1000181

Abstract HTML PDF



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