Lata Singh Author

Short Communication Open Access

Correlation of histopathological high risk factors with Polo-Like Kinase 1 (PLK1) in retinoblastoma

Author(s):

Lata Singh

Retinoblastoma remains a therapeutic challenge for pediatric oncologists. Polo-like kinases (Plks), a family of conserved serine/threonine kinases, are important regulators of cell cycle progression for maintaining DNA integrity. Expression of PLK1 in retinoblastoma has not been studied so far and so its role remains unclear till now. Retrospective analyses of 30 primary enucleated retinoblastoma cases over a period of 2010-2011 were included in this study. PLK1 protein expression was performed by immunohistochemistry in formalin fixed retinoblastoma specimens. Cytoplasmic staining was graded as weak/ negative (1+), moderate (2+) and strong (3+).PLK1 expression was correlated with tumour differentiation and histopathological high risk factors. Th e patients were followed up for one year... view more»

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