Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Laura J. Tafe Author

laura.j.tafe@hitchcock.org 603-650-7211 | 603-650-7211

Subjects of specialization
Colorectal cancer, Cancer chemotherapy, Prostate biomarker

Affiliation
Department of Pathology, Dartmouth Hitchcock, Medical Center, One Medical Center Drive, Lebanon, NH 03756, U.S.A

Biography

Laura J. Tafe was working in the Department of Pathology, Dartmouth Hitchcock, Medical Center, One Medical Center Drive, Lebanon, NH 03756, U.S.A. Doctor has more than 40 publications. Doctor's current research area related to Clinical Oncology.

Publications

Research Article Open Access

HER2 Testing in Gastroesophageal Cancer Paired Biopsy and Resection Specimens, A Multi- Institutional Immunohistochemistry and Fluorescence In-Situ Hybridization Correlation Study

Author(s):

Laura J. Tafe, Jackie Cao, Marlene Sabbath-Solitare, Teresita Cuyegkeng Redondo, Jonathan Lara and Gregory J. Tsongalis

Eligibility for treatment with trastuzumab (Herceptin) for metastatic gastroesophageal cancer (GE) requires demonstration of HER2 protein overexpression or HER2 gene amplification. However, in the US there are no guidelines for best practices of HER2 testing in GE. The goals of this multicenter study were to first evaluate whether the published 2007 ASCO/CAP guidelines established for breast cancer could be extrapolated to GE cancers; and second, to implement an inter-laboratory comparison of HER2 IHC and FISH performance in paired biopsy and tumor resection specimens. Fifty paired formalin-fixed paraffin-embedded (FFPE) biopsy and resection specimens of GE carcinomas were ... view more»

DOI: 10.4172/2324-9110.1000125

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