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Hindi Journal of Diagnostic Techniques and Biomedical AnalysisISSN: 2469-5653
Leslie Z. Benet Author
Subjects of specialization
Affiliation
1-Aminobenzotriaole; P450 inactivator; Induced inhibition; Glucuronidation; Drug metabolism; Toxicity
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, USA
Biography
| Leslie Z. Benet Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, USA |
Publications
Research Article Subscription
The Effects of 1-Aminobenzotriazole Inhibition on the Formation of Acyl-Glucuronide and Acyl-Glutathione Metabolites in Rat Hepatocytes
Author(s): Howard Horng and Leslie Z. Benet
The Effects of 1-Aminobenzotriazole Inhibition on the Formation of Acyl-Glucuronide and Acyl-Glutathione Metabolites in Rat Hepatocytes
1-Aminobenzotriaole (ABT) is a commonly used non-selective mechanism based human and non-human cytochrome P450 (P450) inactivator. However, the direct effects of ABT mediated P450 inhibition on conjugative metabolism, specifically acyl-glucuronide and acyl-glutathione formation has not been previously investigated. In the present study, we evaluated the in vitro effects of ABT induced inhibition of P450 metabolism on the formation of 1-O-acyl-glucuronides of the carboxylic acid-containing drugs gemfibrozil (GEM), tolmetin (TOL), mefenamic acid (MFA), and diclofenac (DCF), and the S-acyl-glutathione formation of MFA and DCF in ... view more»
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