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Hindi Journal of Diagnostic Techniques and Biomedical AnalysisISSN: 2469-5653
Lin Yuan Author
Subjects of specialization
Affiliation
dNEC; cP16; CD8+ T cells; EGR1; HLA class I
Pathology Center, Shanghai General Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China;
Biography
| Lin Yuan Pathology Center, Shanghai General Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, P.R. China |
Publications
Research Article Subscription
Cytoplasmic Expression of P16 is Related to Low Infiltration of CD8+ T cell and Poor Prognosis in Digestive Neuroendocrine Carcinoma
Author(s): Ling-Jun Song, Xue-Mei Zhang, Ting Wang, Lin Yuan, Hao Yue, Guo-Hui Fu and Wei-Wei Shen
Background and Aims: The aim of this study is to examine the predictive and prognostic value of cytoplasmic P16Ink4A (cP16) and poor infiltration of CD8+ T cell in primary digestive neuroendocrine carcinoma (dNEC). Methods: We retrospectively reviewed 86 cases of NEC and mixed NEC (all cases thereafter refer to NEC), which had primary sites in digestive system. Kaplan-Meier survival curves and log-rank test were used for the survival analysis. Bioinformatics analysis was performed to identify the P16-related pathways. Results: The expression frequency of P16 in dNEC and adjacent tissues was 81.4% and 19.3% respectively (p<0.0001). There was no difference in overall survival (OS) between dNEC patients with P16 positive or negative expression. However, there was a statistically lower O... view more»
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