Marco Carnelli Author
Subjects of specialization
Affiliation
Obstetrics, Gynecology Unit, Ospedali Riuniti di Bergamo
Obstetrics and Gynecology Unit, Ospedali Riuniti di Bergamo, Italy
Marco Carnelli was working at Obstetrics and Gynecology Unit, Ospedali Riuniti di Bergamo, Italy. He has more than 25 publications. His current research focuses on Gynecology.
Research Article Open Access
Author(s): Massimo Origoni, Patrizia De Marzi, Giada Almirante, Jessica Ottolina, Luigi Frigerio, Marco Carnelli, Chiara Gelardi and Massimo Candiani
Aneuploidy, defined as an abnormal quantity of DNA in cells nuclei, is the most frequently observed genetic abnormality in cancer cells. Alterations in cell cycle control and chromosomal missegregation very often result in the accumulation of excess genetic material. These genetic reassortments simultaneously imbalance lots of structural and regulatory proteins. This chromosomal instability may be associated with mutations in tumor suppressor genes or loss of function of mismatch repair genes. These are common pathways of cancerogenesis in endometrial cancer. Endometrial cancer represents the most common female genital tract malignancy and is generally associated with favourable outcomes ... view moreĀ»