Marco Carnelli Author

Research Article Open Access

The Prognostic Value of DNA Ploidy Determination in Endometrial Cancer

Author(s):

Massimo Origoni, Patrizia De Marzi, Giada Almirante, Jessica Ottolina, Luigi Frigerio, Marco Carnelli, Chiara Gelardi and Massimo Candiani

Aneuploidy, defined as an abnormal quantity of DNA in cells nuclei, is the most frequently observed genetic abnormality in cancer cells. Alterations in cell cycle control and chromosomal missegregation very often result in the accumulation of excess genetic material. These genetic reassortments simultaneously imbalance lots of structural and regulatory proteins. This chromosomal instability may be associated with mutations in tumor suppressor genes or loss of function of mismatch repair genes. These are common pathways of cancerogenesis in endometrial cancer. Endometrial cancer represents the most common female genital tract malignancy and is generally associated with favourable outcomes ... view more»

DOI: 10.4172/2324-9110.1000105

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