Marcus V Cronauer Author

Research Article Open Access

Loss of the Tumor Suppressor NKX3.1 in Prostate Cancer Cells is Induced by Prostatitis Related Mitogens

Author(s):

Josua Decker‡, Garima Jain‡, Tina Kießling, Philip Sander, Margit Rid, Thomas TF Barth, Peter Möller, Marcus V Cronauer and Ralf B Marienfeld

Objective: Prostate carcinoma (PCa) is the leading causes of cancer-related death in elderly men. Although several risk factors for the development of prostate cancer have been identified, the impact of chronic prostatitis is still a matter of debate. A key event of prostate cancer pathogenesis is the decrease of the homeo box protein NKX3.1 in the luminal epithelial cells of the prostate observed in early pre-cancerous lesions. Furthermore, inactivation of Nkx3.1 in a mouse model led to high incidence of prostatic intraepithelial neoplasia (PIN) formation underscoring the importance of NKX3.1 loss. In this study, we aimed to define t... view more»

DOI: 10.4172/2324-9110.1000160

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