Marianne Klemp Author
Subjects of specialization
Affiliation
Regression analysis; Joint trial analysis; Major depression; Hamilton rating scale of depression
Department of Pharmacology, University of Oslo, Oslo, Norway
Marianne Klemp Department of Pharmacology, University of Oslo, Oslo, Norway |
Research Article Subscription
Author(s): Ivar Aursnes, Ingunn F Tvete, Jorund Gaasemyr, Bent Natvig and Marianne Klemp
Are Both Antidepressant Drug Effects and Test Scores Unspecific?
Background: Disappointingly small clinical effects of antidepressant drugs have recently been reemphasized. It is also unclear to what degree the 17 questions in the Hamilton Rating Scale of Depression and other questionnaires represent true aspects of depression or rather can be said to measure unspecific symptoms.
Methods: Within all clinical study reports concerning citalopram submitted to the Danish Health Authorities before registration in 1988 we identified among 49 studies two studies with placebo groups reporting individual patient scores. A multiple reg... view more»