Mariuxi Viteri Malone Author

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Lack of Association between Angiogenin (AGN) KO Mice with Improvement in Muscle Strength, Resistance,but Decreased in Chances of Tumorigenesis: Observational Study

Author(s):

Mariuxi Viteri Malone, Erika Mejia Hidalgo and Guofu Hu

Background: For quite a while, there has been controversy over whether or not angiogenin is associated with amyotrophic lateral sclerosis (ALS) risk. A lot of meta-analysis has been done in the last few years to support the fact that angiogenin has no relationship in improving the outcome and muscle strength in ALS. In the other hand, for about 3 decades angiogenin has been thought to play an important role in cell survival, growth, and proliferation. Evidence suggests that the expression and activity of ANG increases the odds of developing a variety of human cancers. We present the results of an observational study done in wild type (WT) and angiogenin knock out (ANG -/- KO) mice in order to determine phenotype and different features as exp... view more»

DOI: 10.4172/2324-9110.1000172

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