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Hindi Journal of Nephrology & Renal DiseasesISSN: 2576-3962
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Masashi Okamura Author
Subjects of specialization
Affiliation
diabetes
Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, Japan
Biography
Masashi Okamura Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, Japan. His publications include:1.Ussher JR, Lopaschuk GD, Arduini A (2013) Gut microbiota metabolism of L-carnitine and cardiovascular risk. Atherosclerosis 231: 456-461. 2.Skagen K, Trøseid M, Ueland T, Holm S, Abbas A, et al. (2016) The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis. Atherosclerosis 247: 64-69.
Publications
Research Article Open Access
The Dynamics of Carnitine, γ-butyrobetaine and Trimethylamine N-oxide in Diabetics and the Effects of Changes in Renal Function
Author(s): Susumu Ogawa, Manami Shimizu, Kazuhiro Nako, Masashi Okamura and Sadayoshi Ito
Objectives: In diabetic kidney disease, vascular disorders progress alongside loss of renal function, possibly due to higher blood concentrations of angiopathic substances, such as gamma-butyrobetaine (γBB), produced by gut microbiota that feed on carnitine in dietary red meat. Therefore, we established the hypothesis that urinary γBB excretion declines with decreasing renal function, causing a rise in blood γBB concentration, leading to aggravated vascular injury.
Methods: Our subjects were non-diabetics with normal renal function (N group) and diabetics with reduced renal function (D group). We measured blood concentration and urinary γBB excretion to compare the... view more»
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