Matrone C | Author | SciTechnol | Cell Biology: Research & Thera

Matrone C Author

matronec@auh.rm.dk +45 784 55252 | +45 784 5525

Subjects of specialization
Cell Developmental Biology,Cell Cloning,Cell Regeneration,treatment of diseases,Cell therapy

Affiliation
Department of Medical Biochemistry, University of Aarhus, Denmark

Biography

Matrone C is currently working in Department of Medical Biochemistry at University of Aarhus, Denmark. He has international experience on various programs, and also contributed and participated in different countries for diverse fields of study. Research interests reflect in wide range of publications in various national and international journals.

Publications

Review Article Subscription

NGF and APP Interplay: Focus on YENPTY Motif of Amyloid Precursor Protein and Y682 Residue

Author(s): Basso E and Matrone C

NGF and APP Interplay: Focus on YENPTY Motif of Amyloid Precursor Protein and Y682 Residue

Cholinergic deficits originated from NGF metabolism disruption, represent one of the early changes in Alzheimer’s disease, where abnormal deposition of β-amyloid peptide (Aβ) and phosphorylated Tau define the neuropathological hallmarks of the disorder. A failure in NGF maturation can promote pro-apoptotic pathway activation, through p75 receptor; while lack of NGF signalling can generate an atypical TrkA receptor phosphorylation resulting in neuronal cell death and Aβ toxicity. These evidences suggest a complex interaction between TrkA, p75, and Aβ, whose ... view more»

DOI: 10.4172/2324-9293.1000106

Abstract HTML PDF