M.D. Author

Special Issue Article Open Access

Rapidly Progressive Interstitial Lung Disease in Melanoma Differentiation-Associated Gene 5 (MDA5) Antibody Positive Dermatomyositis

Author(s):

Carmen Montagnon, M.D.a, Caitrin Coffey, M.D.b, Shreyasee Amin, M.D., M.P.Hb, and Ashima Makol, M.B.B.S

A 56-year-old male presented to clinic with a 3-month history of increasing dyspnea, 1-month history of skin lesions, and 2-week history of arthralgias and decreased muscle endurance. Physical exam revealed inspiratory crackles to the midlungs bilaterally, intact muscle strength but fatigability, stiffness of the hands, raised rash on his torso, dry scaly plaques on the fingers, and tender, papular lesions on the palms. He was Jo-1 negative, but melanoma differentiation-associated gene 5 (MDA5) antibody positive. CK and aldolase were normal, but MRI of lower extremity muscles showed patchy muscular edema/inflammation. CT chest showed patchy bilateral groundglass and reticular opacities suggestive of organizing pneumonia. Skin biopsy was consistent with dermatomyositis. The patient was d... view more»

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