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Hindi Journal of Diagnostic Techniques and Biomedical AnalysisISSN: 2469-5653
Melissa D Thompson Author
Subjects of specialization
Affiliation
ER stress; Inflammation; Autophagy; Mitochondrial dysfunction; Hypoxia; Calcium; Lipids; Apoptosis
Vascular Biology Section, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Biography
| Melissa D Thompson Vascular Biology Section, Boston University School of Medicine, Boston, Massachusetts 02118, USA |
Publications
Review Article Subscription
Endoplasmic Reticulum Stress and Related Pathological Processes
Author(s): Yu Mei, Melissa D Thompson, Richard A Cohen and XiaoYong Tong
Endoplasmic Reticulum Stress and Related Pathological Processes
The endoplasmic reticulum (ER) plays a pivotal role in lipid and protein biosynthesis as well as calcium store regulation, which determines its essential role in cell function. Hypoxia, nutrient deprivation, perturbation of redox status and aberrant calcium regulation can all trigger the ER stress response, which is mediated through three main sensors, namely inositol requiring element-1 (IRE-1), protein kinase-like ER kinase (PERK) and activating transcription factor 6 (ATF6). This review explores the interaction of ER stress and ER stress-associated pathological processes, including inflammation, apoptosis, aberran... view more»
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