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Hindi International Journal of Cardiovascular ResearchISSN: 2324-8602
MGJ Nederhoff Author
Subjects of specialization
Affiliation
Myocardial infarction, Inflammation , Vagus nerve stimulation , Autonomic nerve system, Mouse
Department of Anatomy, University Medical Center Utrecht, Room Str.0.201 P.O. Box 85060, 3508AB, Utrecht, The Netherlands.
Biography
MGJ Nederhoff, Department of Anatomy, University Medical Center Utrecht, Room Str.0.201 P.O. Box 85060, 3508AB, Utrecht, The Netherlands, his latest publication involves the topic Effect of Vagus Nerve Stimulation on Tissue Damage and Function Loss in a Mouse Myocardial Infarction Model.
Publications
Research Article Open Access
Effect of Vagus Nerve Stimulation on Tissue Damage and Function Loss in a Mouse Myocardial Infarction Model
Author(s): MGJ Nederhoff*, SAMW Verlinde, T van Zuuren, G Pasterkamp and RLAW Bleys
Introduction
Autonomic regulation of immune functions has increasingly been studied in recent decades. The attenuating effect of the parasympathetic nervous system on inflammatory processes is demonstrated in studies on inflammatory disease like rheumatoid arthritis, chronic bowel disease and heart failure. Similar inflammatory processes play a role in the development of tissue damage following myocardial infarction (MI). In this study, effects of vagus nerve stimulation (VS) on tissue damage and function loss after MI in the mouse heart were measured.
Methods
Anaesthetized male C57Bl6 mice were treated with or without 30 seconds of VS prior to experimental MI. Baseline and terminal heart function were studied. After 48 hours animals were sacrificed and infarct s... view more»
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